Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients.
Identifieur interne : 000724 ( 2020/Analysis ); précédent : 000723; suivant : 000725Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients.
Auteurs : Zhang Yongchen [République populaire de Chine] ; Han Shen [République populaire de Chine] ; Xinning Wang [République populaire de Chine] ; Xudong Shi [République populaire de Chine] ; Yang Li [République populaire de Chine] ; Jiawei Yan [République populaire de Chine] ; Yuxin Chen [République populaire de Chine] ; Bing Gu [République populaire de Chine]Source :
- Emerging microbes & infections [ 2222-1751 ] ; 2020.
Abstract
Effective strategy to mitigate the ongoing pandemic of 2019 novel coronavirus (COVID-19) require a comprehensive understanding of humoral responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the emerging virus causing COVID-19. The dynamic profile of viral replication and shedding along with viral antigen specific antibody responses among COVID-19 patients started to be reported but there is no consensus on their patterns. Here, we conducted a serial investigation on 21 individuals infected with SARS-CoV-2 in two medical centers from Jiangsu Province, including 11 non-severe COVID-19 patients, and 5 severe COVID-19 patients and 5 asymptomatic carriers based on nucleic acid test and clinical symptoms. The longitudinal swab samples and sera were collected from these people for viral RNA testing and antibody responses, respectively. Our data revealed different pattern of seroconversion among these groups. All 11 non-severe COVID-19 patients and 5 severe COVID-19 patients were seroconverted during hospitalization or follow-up period, suggesting that serological testing is a complementary assay to nucleic acid test for those symptomatic COVID-19 patients. Of note, immediate antibody responses were identified among severe cases, compared to non-severe cases. On the other hand, only one were seroconverted for asymptomatic carriers. The SARS-CoV-2 specific antibody responses were well-maintained during the observation period. Such information is of immediate relevance and would assist COVID-19 clinical diagnosis, prognosis and vaccine design.
DOI: 10.1080/22221751.2020.1756699
PubMed: 32306864
Affiliations:
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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Technology School of Xuzhou Medical University, Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou 221004, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Emerging microbes & infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Effective strategy to mitigate the ongoing pandemic of 2019 novel coronavirus (COVID-19) require a comprehensive understanding of humoral responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the emerging virus causing COVID-19. The dynamic profile of viral replication and shedding along with viral antigen specific antibody responses among COVID-19 patients started to be reported but there is no consensus on their patterns. Here, we conducted a serial investigation on 21 individuals infected with SARS-CoV-2 in two medical centers from Jiangsu Province, including 11 non-severe COVID-19 patients, and 5 severe COVID-19 patients and 5 asymptomatic carriers based on nucleic acid test and clinical symptoms. The longitudinal swab samples and sera were collected from these people for viral RNA testing and antibody responses, respectively. Our data revealed different pattern of seroconversion among these groups. All 11 non-severe COVID-19 patients and 5 severe COVID-19 patients were seroconverted during hospitalization or follow-up period, suggesting that serological testing is a complementary assay to nucleic acid test for those symptomatic COVID-19 patients. Of note, immediate antibody responses were identified among severe cases, compared to non-severe cases. On the other hand, only one were seroconverted for asymptomatic carriers. The SARS-CoV-2 specific antibody responses were well-maintained during the observation period. Such information is of immediate relevance and would assist COVID-19 clinical diagnosis, prognosis and vaccine design.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yongchen, Zhang" sort="Yongchen, Zhang" uniqKey="Yongchen Z" first="Zhang" last="Yongchen">Zhang Yongchen</name></noRegion><name sortKey="Chen, Yuxin" sort="Chen, Yuxin" uniqKey="Chen Y" first="Yuxin" last="Chen">Yuxin Chen</name><name sortKey="Gu, Bing" sort="Gu, Bing" uniqKey="Gu B" first="Bing" last="Gu">Bing Gu</name><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><name sortKey="Shen, Han" sort="Shen, Han" uniqKey="Shen H" first="Han" last="Shen">Han Shen</name><name sortKey="Shi, Xudong" sort="Shi, Xudong" uniqKey="Shi X" first="Xudong" last="Shi">Xudong Shi</name><name sortKey="Wang, Xinning" sort="Wang, Xinning" uniqKey="Wang X" first="Xinning" last="Wang">Xinning Wang</name><name sortKey="Yan, Jiawei" sort="Yan, Jiawei" uniqKey="Yan J" first="Jiawei" last="Yan">Jiawei Yan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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